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首页» 教师队伍» 陈英玉 教授»

教师队伍

马大龙 教授(中心主任)
韩文玲 教授(中心副主任)
陈英玉 教授
邱晓彦 教授
王露 教授
王应 教授
赵红珊 教授
黄晶 副教授
张颖妹 副主任技师
宋泉声
王平章
吕平
李婷
莫晓宁
唐玉红(中心秘书)

陈英玉 教授>>

陈英玉教授课题组介绍

  

课题负责人简介

陈英玉,女,19637月出生,山东招远市人,陈英玉,医学博士, 教授,博士生导师,北京大学基础医学院免疫学系,北京大学人类疾病基因研究中心。

研究方向:

1人类功能基因组学,新的细胞凋亡和自噬分子的鉴定、分子机制,及其在肿瘤和自身免疫病中的作用。

2 免疫调节的分子机制研究

基金来源:

  • 2015.1-2017.12国家自然科学基金重大研究计划培育项目:课题编号:91430101经费25万元,参与课题
  • 2014.1-2017.12 国家自然科学基金面上项目:程序性细胞死亡分子5的免疫负向调节作用以及分子机制研究。课题编号:31370898,经费90万元,课题负责人
  • 2014.1-2016.12 北京市自然科学基金面上项目,课题编号:5142008,经费18万元,课题负责人
  • 2014.1-2016.12 教育部博士点专项基金(博导类), 课题编号:20130001110015,经费12万元,课题负责人
  • 2011.1-2015.12: 科技部重大基础研究计划(“973”) 课题:细胞自噬在肿瘤和自身免疫病中的作用。课题编号:2011CB910103,经费532万元,课题负责人
  • 2011.1-2013.12 科技部重大新药创制重大专项课题:原创性全人源单克隆抗体药物研发技术平台的建立及应用。课题编号:2011ZX09506-005,经费129.24万元,子课题负责人
  •  2009.1-2011.12 国家自然科学基金面上项目:PDCD5Tip60相互作用的生物学意义以及分子调控机制研究:课题编号:30871263,经费29万元,课题负责人
  • 2009.1-2010.12 科技部重大新药创制重大专项课题:促凋亡重组蛋白新药人PDCD5治疗肿瘤的临床前研究。课题编号:2009ZX09102-242,经费118.5万元,子课题负责人
  • 2008.1-2010.12 国家自然科学基金面上项目:新的程序性细胞死亡相关基因TMEM166的结构和功能研究。课题编号:30771057,经费30万元,课题负责人
  • 2005.1-2007.12 国家自然科学基金面上项目:PDCD5在非凋亡程序性细胞死亡中的作用及其分子调控机制。课题编号:30470844,经费21万元,课题负责人
  •  2003.9-2004.12 科技部SARS防治基础研究(973计划)课题:SARS病毒X4蛋白的早期诊断意义及免疫损伤机理的研究。课题编号:2003CB514109,经费30万元,课题负责人

主要学习和研究工作经历:

1980.91985.7  山东省滨州医学院医疗系学习,获医学学士学位

1990.91993.7  北京医科大学免疫学教研室学习,获医学硕士学位

1998.92001.7  北京大学基础医学院免疫学系,获得博士学位

2001.72003.6  中国科学院动物研究所生物膜与膜工程国家重点实验室,博士后研究工作。

2006.82007.7 澳大利亚蒙纳士大学(Monash University)医学院访问学者。

2003.7-至今北京大学基础医学院免疫学系,北京大学人类疾病基因研究中心工作,副教授,教授。

联系方式:

地址:北京市海淀区学院路38号,北京大学人类疾病基因研究中心

邮编:100191

电话:010-82802846-420

传真:(010-82801149

Email: yingyu_chen@bjmu.edu.cn

 

课题组目前在读研究生:

胡嘉,博士生(2010-2015

夏丹,博士生(2013-2016

李歌,基础8年制(2008-2016

曲柳静,博士生(2011-2016

赵阳,博士生(2014-2017

苗广艳,博士生(2012-2017

洪杜北琦,基础8年制(2009-2017

林欣,基础8年制(2010-2018

许晨彤,基础8年制(2010-2018

郑辉,硕博生(2013-2018

姜静远,基础本科生(2014-2015

夏艳,硕士生(2015-2018

 

主要论著(* 通讯作者)

  1. Bin Guo, Jie Huang, Wenxian Wu, Du Feng, Xiaochen Wang, Yingyu Chen* and Hong Zhang. The nascent polypeptide-associated complex is essential for autophagic flux.Autophagy, 2014 Oct 1; 10(10):1738-48.
  2. Zhenda Wang, Jia Hu, Ge Li, Liujing Qu, Qihua He, Yaxin Lou, Quansheng Song, Dalong Ma, Yingyu Chen*. PHF23 (plant homeodomain finger protein 23) negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1. Autophagy. 2014 Oct 30:e36439. [Epub ahead of print]
  3. Juan Xiao, Ge Li, Jia Hu, Liujing Qu,Dalong Ma, Yingyu Chen*Anti-inflammatory effectsof recombinant human PDCD5 (rhPDCD5) in arat collagen-induced model of arthritis. Inflammation. 2014, 2014 Sep 2. [Epub ahead of print].
  4. Dong Xu, Liujing Qu, Jia Hu, Ge Li, Ping Lv, Dalong Ma, Mingzhou Guo, Yingyu Chen*. Transmembrane protein 106A is silenced by promoter region hypermethylation and suppresses gastric cancer growth by inducing apoptosis.J Cell Mol Med. 2014 Jun 28. 18(8):1655-1666
  5. Yuanbo Zhao, Beiqi Hongdu, Dalong Ma, Yingyu Chen*. Really interesting new gene finger protein 121 RNF121is a novel Golgi-localized membrane protein that regulates apoptosis. Acta Biochim Biophys Sin (Shanghai). 2014 Jun 13; 46(8):668-674.
  6. Lu Y, Qian R, Xiao J, Xu D, Fu H, Chen Y*.Kirenol, a compound from Herba Siegesbeckiae, induces apoptosis in human chronic myeloid leukemia K562 cells. Pharmazie. 2014 Feb; 69(2):148-53.
  7. Hong Xie, Jia Hu, Huan Pan, Yaxin Lou, Ping Lv, yingyu chen*. Adenovirus vector-mediated FAM176A overexpression induces cell death in human H1299 non–small cell lung cancer cells. BMB Rep. 2014 Feb; 47(2):104-9.
  8. Wu Zhong, Haichuan Zhu, Fugeng Sheng, Yonglu Tian, Jun Zhou, Yingyu Chen, Song Li, and Jian Lin. Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells.Autophagy. 2014 Jul;10(7):1285-300.
  9. Zhao Jiang, Chun-Hua Chen, Ying-Yu Chen, Jing-Yan Han, John Riley,Chang-Man Zhou. Autophagic effect of programmed cell death 5 (PDCD5) after focal cerebral ischemic reperfusion injury in rats. Neurosci Lett. 2014 Apr 30; 566:298-303.
  10.  Li Y, Zhao Y, Hu J, Xiao J, Qu L, Wang Z, Ma D, Chen Y*. A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy. Autophagy. 2013, 9(2):150-63
  11.  Xiao J, Liu C, Li G, Peng S, Hu J, Qu L, Lv P, Zhang Y, Ma D, Chen Y*. PDCD5 negatively regulates autoimmunity by upregulating FOXP3+ regulatory T cells and suppressing Th17 and Th1 responses. J  Autoimmunity, 2013; 4734-44.
  12. Dong Xu, Fan Yang, Huiying He, Jia Hu, Xiaodong Lv, Dalong Ma, Yingyu Chen*.Expression of TMEM166 Protein in Human Normal and Tumor Tissues. Appl Immunohistochem Mol Morphol. 2013,21(6):543-52.
  13.  Chen Y*, Zou Z, Xu A, Liu Y, Pan H, Jin L. Serum programmed cell death protein 5 (PDCD5) levels is upregulated in liver diseases. J Immunoassay Immunochem. 2013, 34(3):294-304.
  14.  Zhao YHu JMiao GQu LWang ZLi GLv PMa DChen Y*. Transmembrane Protein 208: A Novel ER-Localized Protein That Regulates Autophagy and ER Stress. PLOS ONE 2013, 8(5):e64228
  15.  Chang Y, Li Y, Hu J, Guo J, Xu D, Xie H, Lv X, Shi T, Chen Y*. Adenovirus vector-mediated expression of TMEM166 inhibits human cancer cell growth by autophagy and apoptosis in vitro and in vivo. Cancer Lett. 2013, 328(1):126-34,
  16. Wang JF, Guan ZP, Zhang SL, Pei Z, Chen Y, Pan H. Programmed cell death 5 correlates with disease activity and interleukin-17 in serum and synovial fluid of rheumatoid arthritis patients. Chin Med J (Engl). 2013,126(2):296-9
  17.  Li Y, Zhou G, La L, Chi X, Cao Y, Liu J, Zhang Z, Chen Y, Wu B.Transgenic human programmed cell death 5 expression in mice suppresses skin cancer development by enhancing apoptosis. Life Sci. 2013 Jul 10; 92(24-26):1208-14.
  18.  Chen CH, Jiang Z, Yan JH, Yang L, Wang K, Chen Y, Han JY, Zhang JH, Zhou CM. The involvement of programmed cell death 5 (PDCD5) in the regulation of apoptosis in cerebral ischemia/reperfusion injury.CNS Neurosci Ther. 2013 Aug; 19(8):566-76.
  19.  Li T, Wang W, Chen Y, Han W. Preparation and characterization of monoclonal  antibodies against VSTM1. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy.2013, 32(4):283-289.
  20.  Zhou C, Zhong W, Zhou J, Sheng F, Fang Z, Wei Y, Chen Y, Deng X, Xia B, Lin J. Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose rapamycin impairs autophagic flux in cancer cells. Autophagy. 2012, 8(8): 1215–1226.
  21.  Huang J, Wang H, Chen Y, Wang X, Zhang H. Residual body removal during spermatogenesis in C. elegans requires genes that mediate cell corpse clearance. Development. 2012, 139(24):4613-4622.
  22.  Xu L, Hu J, Zhao Y, Hu J, Xiao J, Wang Y, Ma D, Chen Y*. PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway. Apoptosis. 2012, 17(11):1235-45.
  23.  Lu Y, Xiao J, Wu ZW, Wang ZM, Hu J, Fu HZ, Chen Y*, Qian RQ. Kirenol exerts a potent anti-arthritic effect in collagen-induced arthritis by modifying the T cells balance. Phytomedicine. 2012, 19(10):882-9.
  24.  Li L, Khatibi NH, Hu Q, Yan J, Chen C, Han J, Ma D, Chen Y*, Zhou C. Transmembrane protein 166 regulates autophagic and apoptotic activities following focal cerebral ischemic injury in rats. Exp Neurol. 2012, 234(1):181-190.
  25.  Gu C, Zhang J, Chen Y, Lei J. A trigger model of apoptosis induced by tumor necrosis factor signaling. BMC Syst Biol. 2011, 5 (Suppl 1):S13.
  26.  Zhuge C, Chang Y, Li Y, Chen Y, Lei J. PDCD5-Regulated Cell Fate Decision after   Ultraviolet-Irradiation-Induced DNA Damage. Biophys J. 2011, 101(11):2582-2591.
  27.  Chen C, Zhou H, Xu L, Xu D, Wang Y, Zhang Y, Liu X, Liu Z, Ma D, Ma Q, Chen Y*.Recombinant human PDCD5 sensitizes chondrosarcomas to cisplatin chemotherapy in vitro and in vivo. Apoptosis.2010, 15:805–813.
  28.  Chen C, Zhou H, Xu L, Liu X, Liu Z, Ma D, Chen Y*, Ma Q. Prognostic significance of downregulated expression of programmed cell death 5 in chondrosarcoma. J Surg Oncol. 2010, 102(7):838-843.
  29.  Tian S, Lin J, Jun Zhou J, Wang X, Li Y, Ren X, Yu W, Zhong W, Xiao J, Sheng F, Chen Y, Jin C, Li S, Zheng Z, Xia B.Beclin 1-independent autophagy induced by a Bcl-X(L)/Bcl-2 targeting compound, Z18. Autophagy. 2010 6(8):1032-1041.2010.
  30.  Xu L, Chen Y, Song Q, Xu D, Wang Y, Ma D. PDCD5 interacts with Tip60 and functions as a cooperator in acetyltransferase activity and DNA damage-induced apoptosis. Neoplasia, 2009, 11(4): 345-354 (Co-first author)
  31.  Hongwei Yao, Lanjun Xu, Yingang Feng, Dongsheng Liu, Yingyu Chen* Jinfeng Wang. Structure-function correlation of human programmed cell death 5 protein. Arch Biochem Biophys. 2009; 486(2):141-149.
  32. Salvi M, Xu D, Chen Y, Cabrelle A, Sarno S, Pinna LA. Programmed cell death protein 5 (PDCD5) is phosphorylated by CK2 in vitro and in 293T cells. Biochem Biophys Res Commun. 2009 Sep 25; 387(3):606-10.
  33. Lin J, Zheng Z, Li Y, Yu W, Zhong W, Tian S, Zhao F, Ren X, Xiao J, Wang N, Liu S, Wang L, Sheng F, Chen Y, Jin C, Li S, Xia B. A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells. Autophagy. 2009 5(3):314-320
  34. Li H, Wang Q, Gao F, Zhu F, Wang X, Zhou C, Liu C,Chen Y, Ma C, Sun W, Zhang L.Reduced expression of PDCD5 is associated with high-grade astrocytic gliomas. Oncol Rep. 2008; 20(3):573-579.
  35. Yu Chuanfei, Wang Lan, Lv Bingfeng, Lu Yang, Zeng Linge, Chen Yingyu, Ma Dalong, Shi Taiping, Wang Lu. TMEM74, a lysosome and autophagosome protein, regulates autophagy. Biochem Biophys Res Commun. 2008369(2):622-629.
  36.  Lan Wang, Chuanfei Yu, Yang Lu, Pengfei He, Jinhai Guo, Chenying Zhang, Quansheng Song, Dalong Ma,Taiping Shi,Yingyu Chen*. TMEM166, a novel transmembrane protein, regulates cell autophagy and apoptosis. APOPTOSIS, 2007, 12:1489–1502 
  37. Ning Wang, Hou-Shan Lu, Zhen-Peng Guan, Tie-Zheng Sun, Ying-Yu Chen, Guo-Rui Ruan, Zhan-Kun Chen, Jun Jiang, Chu-Jie Bai. Involvement of PDCD5 in the regulation of apoptosis in fibroblast-like synoviocytes of rheumatoid arthritis. APOPTOSIS, 2007; 12(8):1433-1441
  38. Xi Ma, Hongshan ZhaoJingxuan Shan, Feng Long , Yaoyao ChenYingyu ChenYingmei Zhang, Xiao Han, Dalong Ma. PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of ERK pathway. Mol Bio Cell. 2007, 181965-1978.
  39. Linnan Chen, Ying Wang, Dalong Ma and Yingyu Chen* Short interfering RNA against the PDCD5 attenuates cell apoptosis and caspase-3 activity induced by Bax overexpression. APOPTOSIS. 2006,11(1):101-111
  40.  Lei Xiaobo, Chen Yingyu, Du Guanhua, Yu Wenli, Wang Xiaohui, Qu Hong, Xia Bin, He Hongping, Mao Jianhua, Zong Weixing, Liao Xudong, Mehrpou Maryam, Hao Xiaojian and Chen Quan. Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome C release via a conformational change in Bcl-2. FASEB J.2006; 20(12):2147-2149 (Co-first author)
  41. Ting Li, Ji Zhong, Yingyu Chen, Xiaoyan Qiu, Ting Zhang, Dalong Ma, Wenling Han. Expression of Chemokine-Like Factor 1 is Upregulated during T Lymphocyte Activation.Life Science. 2006, 79(6):519-24
  42. Yan-hong Yang, Min Zhao; Wen-Mei Li; Ying-Yu Chen, Bin Kang, You-yong Lu: Expression of Programmed Cell Death 5 Gene Involves in Regulation of Apoptosis in Gastric Tumor cells. Apoptosis. 2006,11(6):993-1001.
  43. Bingfeng LvChuanfei Yu, Yingyu Chen, Yang Lu, Dalong Ma, Taiping Shi, Lu Wang: Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is a novel mitochondria protein with an N-terminal mitochondrial targeting sequence and induces apoptosis. Apoptosis, 2006; 11(9):1489-1501
  44.  Yingyu Chen, Ting Zhang, Ting Li, Wenling Han, Yingmei Zhang, Dalong Ma. Preparation and characterization of monoclonal antibody against CKLF1 using DNA immunization with in vivo electroporation. HYBRIDOMA, 2005, 24 (6):305-308
  45.  Chen Yingyu, Shuang Bao, Tan Yaxia, Meng  Minjie, Han Pu, Mo Xiaoning, Song Quansheng, Qiu Xiaoyan, Luo Xin, Gan Qini, Zhang  Xin, Zheng Ying, Liu Shunai, Wang  Xiaoning, Zhong Nanshan, Ma Dalong. The putative Protein X4 of SARS-CoV is expressed on both virus-infected cells and lung tissue of SARS patients, and inhibitsgrowth of Balb/C 3T3 cell line. Chin Med J(Engl) 2005, 118(4).:267-274
  46. Liu D, Yao H, Chen Y, Feng Y, Chen Y, Wang J. The N-terminal 26-residue fragment of human programmed cell death 5 protein can form a stable alpha-helix having unique electrostatic potential character.Biochem J. 2005, 392:47-54.
  47. Min Rui, Yingyu Chen, Yingmei Zhang, Dalong Ma. Transfer of anti-TFAR19 monoclonal antibody into HeLa cells by in situ electroporation can inhibit the apoptosis. Life Science, 2002, 71(15): 1771-1778
  48.  Yingyu Chen, Ronghua Sun, Wenling Han, Yingmei Zhang, Quansheng Song,  Chunhui Di, Dalong Ma. Nuclear translocation of PDCD5 (TFAR19): an early signal for apoptosis?FEBS Letter2001509(27): 191-1964.

 

发表的中文论文(第一或通讯作者):

1 骅,胡嘉,李艳君,欢,陈英玉。人LC3蛋白在大肠杆菌中的表达纯化及其抗体的制备与鉴定。细胞和分子免疫学杂志,2012, 28(5): 517-519

2 郭金海,王峰,赵丽,石太平,王平章,陈英玉NF-κB报告基因重组腺病毒构建及活性分析北京大学学报( 医学版) 2012446):954-959

3 谢洪,李艳军,陈英玉。线粒体自噬。中国生物化学与分子生物学报,201127 (16) :1081-1087

4常莹,许冬,陈瑶瑶,莫小宁,许兰俊,陈英玉。小鼠抗人磷脂酰肌醇3激酶相互作用蛋白1单克隆抗体的制备和鉴定。细胞和分子免疫学杂志,2010, 26(5):459-461

5许兰俊, 张婷, 邵陆宁, 宋泉声, 韩文玲, 陈英玉。鼠抗人CMTM7单克隆抗体的制备和鉴定。北京大学学报( 医学版) 2008403: 236-240

6陈瑶瑶, 赵云罡, 张婷,许兰俊, 马曦, 赵红珊,陈英玉。抗人PDCD10单克隆抗体的制备和鉴定。北京大学学报(医学版)。2006, 38(6)586-591

7罗昕,张婷,马大龙,陈英玉。鼠抗SARS病毒X4蛋白单克隆抗体的制备和鉴定。北京大学学报(医学版),2005375):485-493

8陈英玉,孙荣华,韩文玲,张颖妹,宋泉声,狄春辉,马大龙。凋亡相关蛋白TFAR19 TF-1细胞凋亡中出现细胞核转位. 北京大学学报医学版,2001332):97-100

9陈英玉,张颖妹,孙荣华,宋泉声,狄春辉,马大龙。抗人凋亡相关蛋白TFAR19的单克隆抗体制备及鉴定。中国医学科学院学报,200022(6):502-505

 

申请专利或授权

1陈英玉马大龙肖娟宋泉声张颖妹许兰俊许冬。人重组蛋白PDCD5在治疗自身免疫病中的应用。中国发明专利授权号:ZL201110204191X,授权日期:2014827

2 陈英玉,马大龙,许冬,李艳君,胡嘉,赵远波,宋泉声。新的凋亡相关分子TMEM106A及其用途。中国发明专利申请号:201210155043.8申请日期:2012.5.18

3马大龙陈英玉、常莹、许冬、李艳军、郭金海、王峰、石太平。重组腺病毒TMEM166作为基因治疗药物在抗肿瘤中的应用。中国发明专利申请号:201110178440.2,申请日期:2011629

4 陈英玉,马大龙,宋泉声,张颖妹, 潘欢,许兰俊。用于检测可溶性PDCD5蛋白的ELISA方法和试剂盒。PCT 国际申请号PCT/CN2011/000066申请日期:2011127中国发明专利申请号:201010034529.7,申请日期:2010121

5 林文翰,陈英玉,顾佳,马大龙, 张婷。Tagalsin C及其同系物在制备抗肿瘤药物中的应用。中国发明专利号:ZL200610081051.7,授权公告日:2009114

6 陈英玉,韩文玲,马大龙,李婷,张婷。人趋化因子的单克隆抗体。中国发明专利号:ZL200510059716.X,授权公告日:200857

 

版权所有:北京大学人类疾病基因研究中心      地址:北京市海淀区学院路38号 邮编:100191    电话: 010-82802846